Overview
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
L-Carnitine (as L-Carnitine Tartrate)
500 mg
†
Top Medical Research Studies
9
L-Carnitine supports weight loss in PCOS
In a well-designed study involving 60 overweight women with polycystic ovary syndrome (PCOS), we looked at the impact of 250 mg oral carnitine supplements over 12 weeks. Those taking carnitine lost an average of 2.7 kg and saw reductions in body mass index, waist, and hip circumferences.
Improvements also included better blood sugar control and lower insulin levels, indicating potential metabolic benefits. However, it’s important to note that carnitine did not influence lipid profiles or free testosterone levels. Overall, while it helped with weight and glucose management, results suggest it may have limitations.
Improvements also included better blood sugar control and lower insulin levels, indicating potential metabolic benefits. However, it’s important to note that carnitine did not influence lipid profiles or free testosterone levels. Overall, while it helped with weight and glucose management, results suggest it may have limitations.
Read More
7
l-carnitine shows modest weight loss effects
We explored whether l-carnitine supplementation could help with weight loss by analyzing 37 clinical trials with nearly 2,300 participants.
Our findings show that l-carnitine can lead to a modest decrease in body weight, body mass index (BMI), and fat mass.
However, it's important to note that no significant impact was observed on waist circumference or body fat percentage.
The most effective dosage appears to be around 2000 mg per day for adults, particularly those who are overweight or obese.
Our findings show that l-carnitine can lead to a modest decrease in body weight, body mass index (BMI), and fat mass.
However, it's important to note that no significant impact was observed on waist circumference or body fat percentage.
The most effective dosage appears to be around 2000 mg per day for adults, particularly those who are overweight or obese.
Read More
7
We analyzed the effects of L-carnitine on weight loss through a systematic review of nine randomized controlled trials involving 911 participants. The results illuminated that those who took L-carnitine lost about 1.33 kg more than those who did not.
However, it's important to note that the amount of weight loss seemed to decrease over time. So, while L-carnitine can assist with weight loss initially, its effectiveness may diminish as time goes on.
However, it's important to note that the amount of weight loss seemed to decrease over time. So, while L-carnitine can assist with weight loss initially, its effectiveness may diminish as time goes on.
Read More
Most Useful Reviews
9
Increased energy
23 people found this helpful
This works! I put my wife on this for energy and weight loss. She has noticed a significant increase in energy and has lost 5 lbs in 2 weeks without any exercise, which is impressive for her as she doesn't lose weight easily. My daughter, who is 18, was very fatigued with a racing heart several times daily. Since using this product, she has regained much more energy and her episodes of lowered heart rate have greatly reduced. P.S. Don't take it late at night as it may keep you awake.
Read More
10
Significant weight loss
4 people found this helpful
This is a very effective weight loss supplement. I have noticed increased energy, reduced appetite and substantial weight loss! I began taking this a month ago while changing my diet to mostly fresh fruits, vegetables, and occasional cooked foods. I lost over 5kg in one month to prepare for a TV show, dropping from about 65kg to under 60kg! The supplement undeniably boosted my weight loss, as I felt energised enough to practice yoga before breakfast after taking one capsule in the morning.
Read More
9
Highly recommended
Great weight loss product, highly recommended.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
- All Researches
9
L-Carnitine supports weight loss in PCOS
In a well-designed study involving 60 overweight women with polycystic ovary syndrome (PCOS), we looked at the impact of 250 mg oral carnitine supplements over 12 weeks. Those taking carnitine lost an average of 2.7 kg and saw reductions in body mass index, waist, and hip circumferences.
Improvements also included better blood sugar control and lower insulin levels, indicating potential metabolic benefits. However, it’s important to note that carnitine did not influence lipid profiles or free testosterone levels. Overall, while it helped with weight and glucose management, results suggest it may have limitations.
Improvements also included better blood sugar control and lower insulin levels, indicating potential metabolic benefits. However, it’s important to note that carnitine did not influence lipid profiles or free testosterone levels. Overall, while it helped with weight and glucose management, results suggest it may have limitations.
Read More
8
We examined the effects of l-carnitine on muscle fibrosis related to cancer cachexia in a mouse model. By administering a dose of l-carnitine, we assessed its impact on muscle function and fibrosis over 14 days. Our findings revealed that l-carnitine significantly alleviated muscle fibrosis, showing a beneficial link with the DTX3L/Runx2/COL1A1 axis involved in muscle health. This suggests that l-carnitine could be a vital therapeutic option for managing muscle degeneration in cancer patients.
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8
We aimed to examine the weight loss effects of liraglutide in obese, insulin-resistant women. By measuring various metabolic markers before and after a 3-month treatment, we found that liraglutide significantly aided weight loss and improved insulin sensitivity. Notably, levels of certain acylcarnitines rose while others dropped, indicating a shift in metabolic health. However, even after treatment, some markers remained elevated compared to healthier control subjects. This shows liraglutide can help with weight management, but more research is needed for complete metabolic balance.
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8
We explored how a weight-loss diet impacts gut metabolites like l-carnitine and its effect on weight loss. In a study involving 510 overweight individuals on different diets, we found that lower levels of l-carnitine and choline were linked to better weight loss results after six months. Notably, those who experienced reductions in these metabolites achieved greater improvements in both body weight and energy metabolism. This suggests these metabolites may help predict how well someone responds to weight-loss diets. Further research is needed, especially with wider populations.
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7
We examined the effects of a lifestyle intervention on weight loss in metabolically healthy and unhealthy obese women. By analyzing serum samples before and after six months, we found significant differences in metabolite profiles like carnitine and tyrosine between the two groups.
While both groups showed changes in metabolite levels, only the metabolically unhealthy group experienced notable weight loss correlated with the reduction in carnitine levels. This suggests that focusing on specific metabolites could be key to enhancing interventions for weight loss.
While both groups showed changes in metabolite levels, only the metabolically unhealthy group experienced notable weight loss correlated with the reduction in carnitine levels. This suggests that focusing on specific metabolites could be key to enhancing interventions for weight loss.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased energy
23 people found this helpful
This works! I put my wife on this for energy and weight loss. She has noticed a significant increase in energy and has lost 5 lbs in 2 weeks without any exercise, which is impressive for her as she doesn't lose weight easily. My daughter, who is 18, was very fatigued with a racing heart several times daily. Since using this product, she has regained much more energy and her episodes of lowered heart rate have greatly reduced. P.S. Don't take it late at night as it may keep you awake.
Read More
10
Significant weight loss
4 people found this helpful
This is a very effective weight loss supplement. I have noticed increased energy, reduced appetite and substantial weight loss! I began taking this a month ago while changing my diet to mostly fresh fruits, vegetables, and occasional cooked foods. I lost over 5kg in one month to prepare for a TV show, dropping from about 65kg to under 60kg! The supplement undeniably boosted my weight loss, as I felt energised enough to practice yoga before breakfast after taking one capsule in the morning.
Read More
9
Highly recommended
Great weight loss product, highly recommended.
Read More
9
Good for weight loss
Good for weight loss.
Read More
9
Will repurchase
Very good, will continue to repurchase, as it is good for weight loss.
Read More
Frequently Asked Questions
9
Increased energy
23 people found this helpful
This works! I put my wife on this for energy and weight loss. She has noticed a significant increase in energy and has lost 5 lbs in 2 weeks without any exercise, which is impressive for her as she doesn't lose weight easily. My daughter, who is 18, was very fatigued with a racing heart several times daily. Since using this product, she has regained much more energy and her episodes of lowered heart rate have greatly reduced. P.S. Don't take it late at night as it may keep you awake.
10
Significant weight loss
4 people found this helpful
This is a very effective weight loss supplement. I have noticed increased energy, reduced appetite and substantial weight loss! I began taking this a month ago while changing my diet to mostly fresh fruits, vegetables, and occasional cooked foods. I lost over 5kg in one month to prepare for a TV show, dropping from about 65kg to under 60kg! The supplement undeniably boosted my weight loss, as I felt energised enough to practice yoga before breakfast after taking one capsule in the morning.
9
Obvious effect
Well packaged, a good helper for fitness and weight loss; the effect is obvious when combined with other supplements.
8
Works effectively
2 people found this helpful
If you want to lose weight, take this supplement. It not only aids weight loss but also strengthens the heart. I can personally attest to its effectiveness. The price is reasonable, and the benefits are significant as stated on the packaging. I give it 5 stars and recommend to choose wisely, as supplements can greatly impact your health.
7
l-carnitine shows modest weight loss effects
We explored whether l-carnitine supplementation could help with weight loss by analyzing 37 clinical trials with nearly 2,300 participants.
Our findings show that l-carnitine can lead to a modest decrease in body weight, body mass index (BMI), and fat mass.
However, it's important to note that no significant impact was observed on waist circumference or body fat percentage.
The most effective dosage appears to be around 2000 mg per day for adults, particularly those who are overweight or obese.
Our findings show that l-carnitine can lead to a modest decrease in body weight, body mass index (BMI), and fat mass.
However, it's important to note that no significant impact was observed on waist circumference or body fat percentage.
The most effective dosage appears to be around 2000 mg per day for adults, particularly those who are overweight or obese.
7
We analyzed data from 192 patients who completed fasting therapy, with 142 receiving L-carnitine infusions. To ensure fairness in our comparison, we matched patients using a propensity score method.
After matching, we observed that the group receiving L-carnitine lost an average of 4.05 kg, compared to 3.25 kg in the non-carnitine group. While both groups showed weight loss and decreases in BMI, L-carnitine enhanced these effects. However, the non-carnitine group experienced greater reductions in diastolic blood pressure and triglycerides. Overall, L-carnitine appears to help support weight loss during fasting therapy without negatively impacting blood glucose levels.
After matching, we observed that the group receiving L-carnitine lost an average of 4.05 kg, compared to 3.25 kg in the non-carnitine group. While both groups showed weight loss and decreases in BMI, L-carnitine enhanced these effects. However, the non-carnitine group experienced greater reductions in diastolic blood pressure and triglycerides. Overall, L-carnitine appears to help support weight loss during fasting therapy without negatively impacting blood glucose levels.
7
We explored the metabolic differences between lean and obese cats, particularly during weight loss efforts. Throughout a 10-week energy restriction phase, we observed that obese cats lost approximately 672 grams. Remarkably, while specific amino acids and acylcarnitines increased in these cats, we found no clear evidence of increased fat breakdown.
This suggests that while energy restriction led to metabolic changes, it didn't noticeably enhance fat oxidation. The findings highlight a need for further study to understand how cats process energy differently, potentially guiding more effective weight loss strategies for our feline friends.
This suggests that while energy restriction led to metabolic changes, it didn't noticeably enhance fat oxidation. The findings highlight a need for further study to understand how cats process energy differently, potentially guiding more effective weight loss strategies for our feline friends.
We analyzed the potential benefits of L-carnitine supplementation on weight loss and other health factors for individuals with type 2 diabetes. After examining 21 randomized trials involving 2041 participants, we noted that taking L-carnitine reduced body mass index slightly and showed improvements in various cardiometabolic markers, such as cholesterol and glucose levels.
Although there were notable effects, particularly at certain doses, the overall impact on weight loss was modest. It's essential to approach these findings with caution due to the variability among studies.
Although there were notable effects, particularly at certain doses, the overall impact on weight loss was modest. It's essential to approach these findings with caution due to the variability among studies.
9
L-Carnitine supports weight loss in PCOS
In a well-designed study involving 60 overweight women with polycystic ovary syndrome (PCOS), we looked at the impact of 250 mg oral carnitine supplements over 12 weeks. Those taking carnitine lost an average of 2.7 kg and saw reductions in body mass index, waist, and hip circumferences.
Improvements also included better blood sugar control and lower insulin levels, indicating potential metabolic benefits. However, it’s important to note that carnitine did not influence lipid profiles or free testosterone levels. Overall, while it helped with weight and glucose management, results suggest it may have limitations.
Improvements also included better blood sugar control and lower insulin levels, indicating potential metabolic benefits. However, it’s important to note that carnitine did not influence lipid profiles or free testosterone levels. Overall, while it helped with weight and glucose management, results suggest it may have limitations.
4
L-carnitine linked to cholesterol improvement
We investigated how gut bacteria metabolites, particularly L-carnitine, affect weight loss and cholesterol levels in adults with obesity. Over two years, participants followed a weight-loss diet while we measured their blood levels of L-carnitine and another metabolite, TMAO, at the start and after six months.
While we observed positive changes in harmful cholesterol levels, particularly those linked to L-carnitine, the overall implications for weight loss remained modest. Thus, while L-carnitine can associate with cholesterol improvement, it may not serve as a standalone weight-loss solution.
While we observed positive changes in harmful cholesterol levels, particularly those linked to L-carnitine, the overall implications for weight loss remained modest. Thus, while L-carnitine can associate with cholesterol improvement, it may not serve as a standalone weight-loss solution.
References
- Saparuddin F, Mohd Nawi MN, Ahmad Zamri L, Mansor F, Md Noh MF, et al. Metabolite, Biochemical, and Dietary Intake Alterations Associated with Lifestyle Interventions in Obese and Overweight Malaysian Women. Nutrients. 2024;16. doi:10.3390/nu16203501
- Lu Z, Wang L, Huo Z, Li N, Tong N, et al. l-Carnitine relieves cachexia-related skeletal muscle fibrosis by inducing deltex E3 ubiquitin ligase 3L to negatively regulate the Runx2/COL1A1 axis. J Cachexia Sarcopenia Muscle. 2024;15:1953. doi:10.1002/jcsm.13544
- Mirrafiei A, Jayedi A, Shab-Bidar S. The Effects of L-Carnitine Supplementation on Weight Loss, Glycemic Control, and Cardiovascular Risk Factors in Patients With Type 2 Diabetes: A Systematic Review and Dose-response Meta-Analysis of Randomized Controlled Trials. Clin Ther. 2024;46:404. doi:10.1016/j.clinthera.2024.03.002
- Grant CE, Godfrey H, Tal M, Bakovic M, Shoveller AK, et al. Description of the fasted serum metabolomic signature of lean and obese cats at maintenance and of obese cats under energy restriction. PLoS One. 2024;19:e0299375. doi:10.1371/journal.pone.0299375
- Heianza Y, Zhou T, He H, DiDonato JA, Bray GA, et al. Changes in gut-microbiota-related metabolites and long-term improvements in lipoprotein subspecies in overweight and obese adults: the POUNDS lost trial. Int J Obes (Lond). 2021;45:2600. doi:10.1038/s41366-021-00939-7
- Hussein NA, Ebied SA, Nour HA, Zaki UK, El-Kotishy SM, et al. Liraglutide treatment and acylcarnitine profiles in Egyptian obese insulin-resistant females. Eur J Pharmacol. 2021;891:173668. doi:10.1016/j.ejphar.2020.173668
- Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A. Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Clin Nutr ESPEN. 2020;37:9. doi:10.1016/j.clnesp.2020.03.008
- Zhang T, Zhang L, Ke B, Sun J, Liu T, et al. L-carnitine ameliorated weight loss in fasting therapy: A propensity score-matched study. Complement Ther Med. 2019;44:162. doi:10.1016/j.ctim.2019.03.020
- Kang M, Yoo HJ, Kim M, Kim M, Lee JH. Metabolomics identifies increases in the acylcarnitine profiles in the plasma of overweight subjects in response to mild weight loss: a randomized, controlled design study. Lipids Health Dis. 2018;17:237. doi:10.1186/s12944-018-0887-1
- Heianza Y, Sun D, Smith SR, Bray GA, Sacks FM, et al. Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial. Diabetes Care. 2018;41:413. doi:10.2337/dc17-2108
- Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2016;17:970. doi:10.1111/obr.12436
- Nazari M, Saberi A, Karandish M, Neisi N, Jalali MT, et al. Influence of L-carnitine on the Expression Level of Adipose Tissue miRNAs Related to Weight Changes in Obese Rats. Pak J Biol Sci. 2016;19:227. doi:10.3923/pjbs.2016.227.232
- Samimi M, Jamilian M, Ebrahimi FA, Rahimi M, Tajbakhsh B, et al. Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2016;84:851. doi:10.1111/cen.13003
